Meetings Plenary and Parallel Sessions

Please note that the schedule is subject to change

The oral and poster notifications have been sent to presenting authors in March. If you have not received your notification email, please contact us at Meetings@ShockSociety.org.
 

Saturday, June 8, 2019

5:00 PM – 6:00 PM
Shock Presidential Address
Resilience to Succeed When You Fail
Marc Jeschke, MD, PhD, FACS, FCCM, FRCS(C), Sunnybrook Research Institute, Toronto, Canada

7:00 PM – 9:00 PM
Mentoring and Diversity Program

7:00 PM – 8:00 PM
Session Chair: Elizabeth J. Kovacs, PhD, University of Colorado Denver, Aurora, CO

What Is A Successful NIH Grant Application? Thoughts on How to Get from Here to There
Scott D. Somers, PhD, National Institute of General Medical Sciences, NIH

8:00 PM – 9:00 PM
Session Chair: Melanie Scott,  MD, PhD, University of Pittsburgh, Pittsburgh, PA

Mentoring in the #MeToo Movement
Diana Lautenberger, M.A.T., Director, Women in Medicine and Science, Association of American Medical Colleges (AAMC), Washington, DC

Panel Discussion
Diana Lautenberger, M.A.T, AAMC, Washington, D.C.
Frederick Moore, MD, University of Florida, Gainesville, FL
Alfred Ayala, PhD, Rhode Island Hospital, Providence, RI
Clifford Deutschman, MD, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY

Sunday, June 9, 2019

9:00 AM – 11:00 AM
Plenary Session I: Sepsis: Definitions, Models and Opportunities

Co-Chairs:
Clifford Deutschman, MD, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY
Heather Evans, MD, Medical University of South Carolina, Charleston, SC

In Memory of Basil Pruitt, Jr., MD, FACS, FCCM, MCCM                                    
Tina Palmieri, MD, University of California, Davis, Sacramento, CA

Refining Animal Models of Sepsis
Marcin F. Osuchowski, DVM, PhD, Ludwig Boltzmann Institute, Vienna, Austria

What Are the “Right” Endpoints in Animal Models of Sepsis?
Clifford Deutschman, MD, Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, NY

Sepsis Research at the National Institutes of Health
Sarah Dunsmore, PhD, National Institute of General Medical Sciences, NIH, Bethesda, MD

BARDA's Solving Sepsis Program
Timothy Buchman, MD, PhD, Biomedical Advanced Research and Development Authority, Washington, D. C.

Clinical Trials: Better Design, More Meaningful Outcomes
Catherine L. Hough, MD, University of Washington, Seattle, WA

11:30 AM – 12:30 PM    
Keynote Address

Introduction: Laurie Kilpatrick, PhD, Lewis Katz School of Medicine at Temple University, Philadelphia, PA

Metabolic Reprogramming as a Key Driver of Inflammation and Innate Immunity
Luke O'Neill, PhD, The University of Dublin, Trinity College Dublin, Dublin, Ireland

12:30 PM - 1:30 PM
Oral Presentations By and For New Investigators

Moderator: Wenjun Martini, PhD, US Army Institute of Surgical Research, FT Sam Houston, TX

A Year-Long Immune Profile of the Systemic Response in Acute Stroke Survivors 
Amy Tsai, BA, Stanford University School of Medicine, Stanford, CA

Dedifferentiation and Necrosis of Functional Pancreatic β Cells as Mechanism of             
Diabetes Mellitus Following Acute Pancreatitis
Qiao Shi, PhD, SUNY Upstate Medical University, Syracuse, NY

Loss of Efferent Arteriolar Resistance from AT-1R Modulation May Contribute to Acute
Kidney Injury after Cecal Ligation and Puncture (CLP)                
Daniel Leisman, BS, Feinstein Institute for Medical Research, Manhasset, NY

Anti-CD28 Antibody Improves Survival in “Memory Mice” with Sepsis via Il-10 Released by
Regulatory T Cells             
Yini Sun, MD, Emory University, Atlanta, GA

1:30 PM – 2:45 PM    
New Investigator Award Competition

Moderator: Weng-Lang Yang, PhD, Albert Einstein College of Medicine, Bronx, NY

Reduction of PKA-mediated Lipolysis with Acipimox Improves Mitochondrial Coupling in Adipose Tissue Following Burn Injury
Dalia Barayan, BS, Sunnybrook Research Institute, Toronto, Canada

An Aging-related Single Nucleotide Polymorphism is Associated with Distinct Inflammatory Profiles in Aged Blunt Trauma Patients
Ashley Lamparello, MD, University of Pittsburgh, Pittsburgh, PA

Antithrombin III Contributes to the Protective Effects of Fresh Frozen Plasma Following Hemorrhagic Shock by Preventing Syndecan-1 Shedding and Endothelial Barrier Disruption
Ernesto Lopez, MD, PhD, University of Texas Health Science Center at Houston, Houston, TX

Herpes Virus Entry Mediator (HVEM) Signaling in Neonatal Sepsis
Michelle Wakeley, MD, Warren Alpert Medical School of Brown University, Providence, RI

Regulatory Roles of Human SP-B Variants on Genetic Susceptibility to Pneumonia-induced Sepsis
Fengyong Yang, MD, SUNY Upstate Medical University, Syracuse, NY

2:45 PM – 3:50 PM    
Research Award Recipient Presentations

Moderator: Weng-Lang Yang, PhD, Albert Einstein College of Medicine, Bronx, NY

TLR7 Deficiency Attenuated Acute Lung Injury in Polymicrobial Sepsis
Lin Zou, MD, PhD, University of Maryland School of Medicine, Baltimore, MD
2017 Faculty Research Award Recipient 

Thrombus Site-selective Delivery of Hydroxychloroquine Using Platelet-Targeted Nanovesicles (PTNs) to Attenuate Thrombus Growth in Deep Venous Thrombosis (DVT)
Jurgis Alvikas, MD, University of Pittsburgh, Pittsburgh, PA
2018 Research Investigator Fellowship Recipient 

Transplantation of Bone Marrow-derived Mononuclear Cells Can Attenuate Acute Inflammation and Organ Dysfunction in Rat Heatstroke
Yutaka Umemura, MD, Osaka University Graduate School of Medicine, Osaka, Japan
2018 Japan Shock Society Young Investigator Award Winner

A Vortex-aided Microfluidic Device for a Size-based Cell Sorting
Yuto Takagi, MSc, Mie University Graduate School of Medicine, Tsu-city, Japan
2018 Japan Shock Society Young Investigator Award Winner

4:10 PM – 6:00 PM
Parallel Session I: Innovations in Burn Research
Co-Chairs:
Celeste Finnerty, PhD, University of Texas Medical Branch, Galveston, TX
Tina Palmieri, MD, University of California, Davis, Sacramento, CA
Steven Wolf, MD, University of Texas Southwestern Medical Center, Dallas, TX

Innovations in the Diagnosis and Management of AKI in Burns
COL Kevin K. Chung, MD, Uniformed Services University of the Health Sciences, Bethesda, MD

Strategies for Prevention of Sepsis
Steve E. Wolf, MD, University of Texas Medical Branch, Galveston, TX

What Is on the Horizon for Dermal and Epidermal Regeneration in Burn Patients
Marc Jeschke, MD, PhD, Sunnybrook Research Institute, Toronto, Canada

Advances in Providing Patient-Centered Geriatric Burn Care
Herb Phelan, MD, University of Texas Southwestern Medical Center, Dallas, TX

Beta-Adrenergic Receptor Signaling Modulates Cardiac Mitochondrial Proteins
Amina El Ayadi, PhD, University of Texas Medical Branch, Galveston, TX

Systemic IL-6 Trans-Signaling Contributes to Innate Immune Suppression after Burn Injury
Devin M. Boe, BA, University of Colorado Denver, Aurora, CO

4:10 PM – 6:00 PM
Parallel Session II: Neutrophils in Inflammation: Two Sides of the Same Coin
Co-Chairs:
Jeyaseelan (Jey) Samithamby, PhD, DVM, Louisiana State University,  Baton Rouge, LA
Barbara Sherry, PhD, Feinstein Institute for Medical Research, Manhasset, NY

CXCL1 Regulates Neutrophil Homeostasis in Pneumonia-Derived Sepsis Caused by Gram-positive Bacteria
Samithamby (Jey) Jeyaseelan, PhD, DVM, Louisiana State University,  Baton Rouge, LA

Protein Kinase C-delta Regulation of Neutrophil-Endothelium Interaction Under Shear Flow
Mohammad Kiani, PhD, Temple University, Philadelphia, PA

In Situ Neutrophil Efferocytosis Shapes T Cell Immunity
Minsoo Kim, PhD, University of Rochester, Rochester, NY

Modulating Neutrophil Function: From Bench to Bedside
Jyotika Sharma, PhD, University of North Dakota, Grand Forks, ND

Inducing Neutrophil-Specific Granulopoiesis Using CpG-ODN Conditioned Mesenchymal Stromal Cells in an Experimental Model of Neutropenic Sepsis
Julie Ng, MD, Brigham and Women's Hospital, Boston, MA

The Role of CIRP on NET-Forming ICAM-1+ Neutrophils in Sepsis
Monowar Aziz, PhD, Feinstein Institute for Medical Research, Manhasset, NY

Monday, June 10, 2019

9:00 AM – 10:40 AM
Plenary Session II: Incorporating Microbiome Sciences into Your Thinking, Practice and Research

Co-Chairs:
John Alverdy, MD, University of Chicago, Chicago, IL
Susannah E. Nicholson, MD, University of Texas Health Science Center at San Antonio, San Antonio, TX

Shifting Microbiomes During Injury Directly Influence the Host Immune Program, Sepsis-related Microbiology and Outcome: a Strain-level Analysis
John Alverdy, MD, University of Chicago, Chicago, IL

Shock and the Microbiome
Susannah Nicholson, MD, University of Texas Health Science Center at San Antonio, San Antonio, TX

Nutrition and the Microbiome
Victoria Gershuni, MD, MSGM, University of Pennsylvania, Philadelphia, PA

Inflamm-Aging and Dysbiosis of the Fecal Microbiome: Multi-Organ System Response after Burn Trauma
Elizabeth Kovacs, PhD, University of Colorado Denver, Aurora, CO

11:00 AM -- 12:00 PM
Mini Symposium I: Novel Therapeutic Targets
Co-Chairs: 
Laurie Kilpatrick, PhD, Temple University School of Medicine, Philadelphia, PA
Ping Zhang, MD, PhD, Northeast Ohio Medical University, Rootstown, OH 

Electroporation-Mediated Lung Gene Transfer of Human Feline Sarcoma Related (FER) Tyrosine-Kinase Mobilizes CD8+ Cells into Alveoli and Improves Survival in Murine Model of Gram-Negative Pneumonia
Vladislav Dolgachev, PhD, University of Michigan, Ann Arbor, MI

Topical Neck Cooling Without Systemic Hypothermia Attenuates Myocardial Ischemia-Reperfusion Injury
Aimee Zhang, MD, University of Virginia, Charlottesville, VA

Multivalent Adhesion Molecule (MAM7) Inhibits S. Aureus Infection in a Surgical Incision Rat Model
Dang-Huy Do, BA, University of Texas Southwestern Medical Center, Dallas, TX

Mechanisms Underlying Decreased Mortality with CTLA-4 Checkpoint Inhibition in a Model      
of Murine Sepsis with Premorbid Chronic Alcohol Exposure
LT Cameron W. Paterson, MD, United States Navy and Emory University, Atlanta, GA

Mini Symposium II: Multisystem Trauma and Traumatic Brain Injury (TBI) 
Co-Chairs: 
Michaela A. West MD, PhD, North Memorial Health, Minnetonka, MN 
Vanessa Nomellini, MD, PhD University of Cincinnati, Cincinnati, OH

Nonlinear Dynamics Analysis of Swine Heart Rate Variability can detect Traumatic Brain Injury within 1 Hour of Injury
Min Zhu, MD, PhD, University of Texas Medical Branch, Galveston, TX

Trigeminal Nerve Stimulation Reduces Traumatic Hemorrhage in Murine Hemophilia A
Jared Huston, MD, North Shore University Hospital, Northwell Health, Feinstein Institute for Medical Research, New Hyde Park, NY and Zucker School of Medicine at Hofstra/ Northwell, Hofstra University, Hempstead, NY 

Early Monocyte Depletion Improves Long-Term Learning, Memory, and Skill Acquisition in Mice after Traumatic Brain Injury
Mecca Islam, MS, Northwestern University, Chicago, IL

Antibiotic-Induced Gut Dysbiosis and the Systemic Inflammatory Response after       
Traumatic Brain Injury
Akshita Kumar, MD, University of Texas Health Science Center at Houston, Houston, Texas

Tuesday, June 11, 2019

9:00 AM – 11:15 AM
Parallel Session III: Trauma and Resuscitation
Co-Chairs:
Rosemary Kozar, MD, PhD, University of Maryland, Baltimore, MD
Anthony Pusateri, PhD, US Army Medical Research and Material Command, Fort Detrick, MD

Prehospital Tranexamic Acid Improves Survival After Traumatic Brain Injury in Patients with Intracranial Hemorrhage
Martin Schreiber, MD, Oregon Health & Science University, Portland, OR

Tranexamic Acid in Trauma: What Have We Learned?
COL Andrew P. Cap, MD, PhD, US Army Institute of Surgical Research, Fort Sam Houston, TX

Prehospital Plasma Resuscitation of Hemorrhagic Shock in an Urban Ground Ambulance Transport System Does Not Improve Survival: A Pragmatic, Randomized Trial
Ernest E Moore, MD, University of Colorado Denver, Denver, CO

The Prehospital Air Medical Plasma (PAMPer) Trial: Implications For Traumatic Injury
Jason Sperry, MD, University of Pittsburgh, Pittsburgh, PA

Prehospital Plasma Transfusion Improves Survival in Trauma Patients with Longer Prehospital Transports
Anthony Pusateri, PhD, US Army Medical Research and Material Command, San Antonio, TX

Hemorrhage as Conditioning for Murine Myeloid Progenitor Engraftment
Joshua T. Cohen, MD, Rhode Island Hospital, Providence, RI

In Hospital Treatment with Remote Ischemia Conditioning Alters Early Post-Traumatic            
Changes in Coagulation in Resuscitated Hemorrhagic Shock Patients
Chung Ho Leung, BSc, University of Toronto, Toronto, Canada

9:00 AM – 11:15 AM
Parallel Session IV: Precision Medicine in Surgery, Trauma, and Critical Care
Co-Chairs:
Judith Hellman, MD, University of California, San Francisco, CA
Yoram Vodovotz, PhD, University of Pittsburgh, Pittsburgh, PA

Computational and Systems Biology of Trauma: Basic and Translational Insights
Yoram Vodovotz, PhD, University of Pittsburgh, Pittsburgh, PA

Combining Clinical and Biological Variables to Reduce Heterogeneity in ARDS
Michael Matthay, MD, University of California, San Francisco, CA

Use of Precision Medicine to Direct Glucocorticoid Sepsis Therapy
Xiang-An Li, PhD, University of Kentucky, Lexington, KY

Shifting Gears - Biological Hallmarks of Surgical Recovery
Martin Angst, MD, Stanford University, Stanford, CA

Sarcopenia Is Associated with Poor Long-Term Functional Status and Mortality Following Intra-Abdominal Sepsis
Michael C. Cox, MD, University of Florida, Gainesville, FL

Early Prediction and Prevention of Enteritis and Secondary Bacterial Translocation After Major Operations
Jian Zhang, PhD, First Affiliated Hospital of Zhejiang University, Hangzhou, China

Fluctuation of the Olfactomedin-4 positive Neutrophil Subset in Adult Blunt Trauma Patients
Nick C. Levinsky, MD, University of Cincinnati College of Medicine, Cincinnati, OH

11:30 AM – 12:30 PM
Mini Symposium III: Sepsis
Co-Chairs:
Mitchell J Cohen, MD, University of Colorado Denver, Aurora, CO
Stephen W. Standage, MD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Novel Synthetic Toll-like Receptor 4 Agonists Enhance Resistance to Infection with Common Bacterial Pathogens
Antonio Hernandez, MD, Vanderbilt University, Nashville, TN
 
Polymicrobial Sepsis Induces Aberrant Activation of Splenic Dendritic Cells in Neonatal Mice
Jaimar C. Rincon, PhD, University of Florida, Gainesville, FL 
 
Endothelial Specific HSPA12B Prevents Upregulation of Adhesion Molecules in Sepsis
Min Fan, MD, East Tennessee State University, Johnson City, TN
 
Dysfunctional Dynamics within the Hippocampus in Long-Term Sepsis Surviving Mice Lead to Altered Spatial Coding
Joshua J. Strohl, BS, Feinstein Institute for Medical Research, Manhasset, NY

Mini Symposium IV: Barrier Function
Co-Chairs: 
Lorraine Ware, MD Vanderbilt University, Nashville, TN
Mashkoor A.  Choudhry, PhD Loyola University of Chicago, Maywood, IL

Genetic Deficiency of AMPKα1 Worsens Gut and Endothelial Barrier Dysfunction after Mesenteric Ischemia and Reperfusion Injury in Mice
Hannah V. Lewis, MD, University of Cincinnati, Cincinnati, OH

The Ex Vivo Perfused Human Lung is Resistant to Alveolar Epithelial Injury from High-Dose S. Pneumoniae Bacteremia 
James T. Ross, MD, University of California San Francisco, San Francisco, CA
 
Dysregulation of Intrinsic MicroRNAs Contribute to Human Vascular Leak in an Ex Vivo Model of Sepsis 
Rebecca L. Watkin, BSc, Royal College of Surgeons in Ireland, Dublin, Ireland
 
Regenerative Peptide TP508 Attenuates Neuroinflammation, Induces Neurogenesis and Reverses Endothelial Dysfunction in Experimental Traumatic Brain Injury
Amit K. Srivastava, PhD, The University of Texas Health Science Center at Houston, Houston, TX

12:30 PM – 1:30 PM
Oral Presentations By and For New Investigators: Highlighting Diversity in Science

Moderator: Antonio Davila Jr., PhD, University of Pennsylvania, Philadelphia, PA

Evaluation of Innate Immune Cell Reprogramming Using Cargo-less Nanoparticles to Ameliorate Severe Inflammation
Jackline Joy Lasola, ScM, University of Maryland School of Pharmacy, Baltimore, MD
 
A Modified Storage Solution Decreases Red Blood Cell Storage Lesion Formation and Inflammatory Response to Resuscitation Following Hemorrhagic Shock 
Kasiemobi Pulliam, PhD, University of Cincinnati, Cincinnati, OH
 
Tyrosine Phosphorylation of Caspase-8 Induces Cell Activation through Toll-Like Receptor 4 Dependent Signaling in Septic Neutrophils
Sahil Gupta, HBSc, St. Michael's Hospital/ University of Toronto, Toronto, Canada
 
Inhibition of Trem-1 with a Cirp-Derived Peptide Protects Mice from Intestinal Ischemia/Reperfusion Injury
Naomi-Liza Denning, MD, Feinstein Institute for Medical Research at Northwell Health, New Hyde Park, NY

1:30 PM – 3:30 PM
Plenary Session III 
Top Submitted Abstracts
Co-Chairs:
Elizabeth Kovacs, PhD, University of Colorado Denver, Aurora, CO
Marc Jeschke MD, PhD, Sunnybrook Research Institute, Toronto, Canada

Mitochondrial CX43 and GJA1-20K in Estrogen-Mediated Cardiac Protection Following Acute Ischemia/Reperfusion
Meijing Wang, MD, Indiana University School of Medicine, Indianapolis, IN
 
Therapeutic Potential of Natural and Engineered Chemokine (C-X-C Motif Receptor 4 Agonists in a Combined Lung Ischemia-Reperfusion Injury and Hemorrhage Model of Acute Respiratory Distress Syndrome 
Favin S. Babu, MD, Loyola University Chicago, Chicago, IL
 
Human Neutrophil Transcriptomic Changes in Premature Infants Fail to Resolve Despite Reaching Term-Corrected Gestational Age
Russell B. Hawkins, MD, University of Florida, Gainesville, FL
 
Trauma Induces Emergency Hematopoiesis through IL-1 mediated production of G-CSF
Isaiah R. Turnbull, MD, PhD, Washington University School of Medicine, St. Louis, MO

Circulating Cell-Free Nuclear DNA is Associated with Fibrinolytic Shutdown After Injury 
Matthew E. Kutcher, MD, University of Mississippi Medical Center, Jackson, MS

Increased Expression of Adipose-Derived PAI-1 is Associated with Acute Kidney Injury in Murine Models and Septic Patients  
Beverly K. Balasuriya, PhD, University of Kentucky, Lexington, KY

Modulation of Oxidative and Nitrosative Stress Attenuates Microvascular Hyper-Permeability in Ovine Septic Shock 
Satoshi Fukuda, MD, University of Texas Medical Branch, Galveston, TX

T Cell Memory Enhances Pulmonary Innate Immune Responses and Inflammatory Cytokine Production Following Cecal Ligation and Puncture (CLP)
Mariana R. Brewer, MD, The Feinstein Institute for Medical Research, Manhasset, NY

3:45 PM – 5:30 PM
Parallel Session V: Precision Medicine for Susceptible Populations to Critical Illness: Tailoring Therapy and Treatment
Co-Chairs:
Philip Efron, MD, University of Florida, Gainesville, FL
Jennifer Kaplan, MD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Sepsis and Older Adults
Phil Efron, MD, University of Florida, Gainesville, FL

The Effect of Obesity during Critical Illness: Helpful or Harmful?
Jennifer Kaplan, MD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Impact of Cancer on Immune Dysregulation During Sepsis
Mandy Ford, PhD, Emory University, Atlanta, GA

Modifiable Determinants of Neonatal Sepsis-Induced Brain Injury
James Wynn, MD, University of Florida, Gainesville, FL

Outcomes after Abdominal Surgery for Trauma in Obese Patient  
Elinore J. Kaufman, MD, University of Pennsylvania, Philadelphia, PA

Bariatric Surgery Does Not Improve Innate Immune Dysfunction Obese Diabetic Mice
Lynn M. Frydrych, MD, University of Michigan, Ann Arbor,  MI

3:45 PM – 5:30 PM
Parallel Session VI: Cell Signaling in Infection and Inflammation
Co-Chairs:
Melanie Scott, MD, PhD, University of Pittsburgh, Pittsburgh, PA
Ben Lu, MD, PhD  Central South University, Changsha, China

A Critical Protein Kinase Controls Inflammation, Wound Repair, and Cancer at Sites of Inflammation
Michael Yaffe, MD, PhD, Massachusetts Institute of Technology, Cambridge, MA

The Endocannabinoid and Endovanilloid Systems in Innate Immunity and Sepsis
Judith Hellman, MD, University of California, San Francisco, CA

Inflammatory Caspases in Trauma/Hemorrhagic Shock
Melanie Scott, MD, PhD, University of Pittsburgh, Pittsburgh, PA

IRF3 Signaling in Stromal Cells Contributes to Sepsis Pathogenesis
Wendy Walker, PhD, Texas Tech University Health Science Center, El Paso, TX

Immunoresponsive Gene 1 and Itaconate: Key mediators of TLR4 agonist-induced protection against infection     
Naeem K. Patil, MD, PhD, Vanderbilt University, Nashville, TN
 
Pyruvate Dehydrogenase Controls Anabolism and Catabolism in Monocytes: Implications for Mitochondrial Targeting During Sepsis   Charles E. McCall, MD, Wake Forest University, Winston-Salem, NC
 

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