Meetings Plenary and Parallel Sessions

 


Saturday, June 9, 2018


1:00 PM - 3:00 PM
Plenary Session I: Integration and Connectivity in Shock Research
Moderators:
Timothy R. Billiar, MD, University of Pittsburgh, Pittsburgh, PA
Melanie Scott, MD, PhD, University of Pittsburgh, Pittsburgh, PA

1:00 PM – 1:30 PM          
40th Anniversary Opening Remarks 
 
1:30 PM – 2:00 PM          
Role of NF-kappaB Activation in LY6C+ Monocytes in Necroizing Enterocolitis
Isabelle G. De Plaen, MD, Northwestern University Feinberg School of Medicine, Chicago, IL
 
2:00 PM – 2:30 PM          
Chemical Interventions in Cellular Stress Pathways
Peter Wipf, PhD, University of Pittsburgh, Pittsburgh, PA
 
2:30 PM – 2:45 PM          
Increased Survival in the Absence of TLR-3 is Attributed to Improved Bactericidal Activity of the Alveolar Macrophage in a Murine Model of Klebsiella Pneumoniae 
Madathilparambil V. Suresh, PhD, University of Michigan, Ann Arbor, MI
 
2:45 PM – 3:00 PM          
Transcriptional Control of Skeletal Muscle Bioenergetics in Patients with Severe Burns
Evan Ross, MD, The University of Texas Medical Branch, Galveston, TX

3:30 PM - 5:30 PM
Plenary Session II: The Science of Shock: Talks Selected from Submitted Abstracts
Moderators:
Elizabeth J. Kovacs, PhD, University of Colorado Denver, Aurora, CO
Kevin Mollen, MD, University of Pittsburgh Medical Center, Pittsburgh, PA

3:30 PM – 3:45 PM          
Myeliod-specific Deletion of Arginase-1 Enhances Post-burn Pulmonary Immune Responses Against Pseudomonas Aeruginosa Pneumonia
Devin M. Boe, BA, University of Colorado Denver, Aurora, CO
 
3:45 PM – 4:00 PM          
Hapatic Cellular Stress Induces Periportal Progenitor Cells Proliferation which Contributes to Prolonged Inflammatory Response and Hypermetabloism after Severe Trauma Injury
Li Diao, MD, Sunnybrook Research Institute, Toronto, Canada
 
4:00 PM – 4:15 PM          
GM-CSF Improves Innate Immune Dysfunction and Sepsis Survival in Obese Diabetic Mice
Lynn M. Frydrych, MD, Department of Surgery, University of Michigan, Ann Arbor, MI
 
4:15 PM – 4:30 PM          
Kidney Proximal Tubular TLR9 Exacerbates Ischemic Acute Kidney Injury
Sang Jun Han, PhD, College of Physicians and Surgeons of Columbia University, New York, NY
 
4:30 PM – 4:45 PM          
Benefits and Harms of Early Prophylactic Inferior Vena Cava Filter in Major Trauma Patients:  A Mulitcenter Randomized-Controlled-Trial (RCT)
Kwok Ming Ho, PhD, MPH, Royal Perth Hospital and University of Western Australia, Perth, Western Australia
 
4:45 PM – 5:00 PM          
Anti-PD-L1 Attenuates T Cell Dysfunction and Protects Against Infection with Common Nosocomial Pathogens after Severe Burn Injury
Naeem Patil, MD, PhD, Vanderbilt University Medical Center, Nashville, TN
 
5:00 PM – 5:15 PM          
Regulation of Intestinal  Bacterial Translocation by Intestinal Lamina Propria Dendritic Cells Expressing TLR5 after Trauma/Hemorrhagic Shock
Jian Zhang, PhD, Zhejiang University, Hang Zhou, China
 
5:15 PM – 5:30 PM          
Endothelial Progenitor Cells Exosomes Improve the Outcome of a Murine Model of Sepsis through MIR-126
Yue Zhou, PhD, Nanjing University of Chinese Medicine, Nanjing, China and Medical University of South Carolina, Charleston, SC

 

Sunday, June 10, 2018

1:30 PM – 2:45 PM    
NEW INVESTIGATOR COMPETITION

Moderator:  
Weng-Lang Yang, PhD, The Feinstein Institute for Medical Research, Manhasset, NY

1:30 PM – 1:45 PM       
Cold-inducible RNA-binding Protein Induces Neutrophil Reverse Transendothelial Migration via Neutrophil Elastase-dependent Reduction of Junctional Adhesion Molecule-C in Lungs in Sepsis
Hui Jin, MD, PhD, The Feinstein Institute for Medical Research, Manhasset, NY
 
1:45 PM – 2:00 PM       
Burn-induced Microglia Activation is Associated with Motor Neuron Degeneration and Muscle Wasting in Mice
Li Ma, MD, PhD, Massachusetts General Hospital, Boston, MA and Burn Institute, Beijing, China
 
2:00 PM – 2:15 PM       
Acid Sphingomyelinase Inhibition Reduces Neuropathologic Findings After Traumatic Brain Injury
Grace E. Martin, MD, University of CIncinnati, Cincinnati, OH
 
2:15 PM – 2:30 PM       
Protein Kinase C-Delta (PKCδ)  Tyrosine Phosphorylation is a Critical Regulator of Neutrophil-endothelial Cell Interactions in Inflammation
Fariborz Soroush, PhD Candidate, Temple University, Philadelphia, PA
 
2:30 PM – 2:45 PM       
Surfactant Protein D Alleviates Severe Acute Pancreatitis-induced Inflammation and Injury by Suppressing NLRP3 Inflammasome Activation and NF-κB Signaling Pathway
Jia Yu, MD, PhD, SUNY Upstate Medical University, Syracuse, NY

2:50 PM – 3:50 PM    
RESEARCH FELLOWSHIP RECIPIENT PRESENTATIONS

Moderator:  
Weng-Lang Yang, PhD, The Feinstein Institute for Medical Research, Manhasset, NY

2:50 PM – 3:10 PM       
Innate Immune Dysfunction Drives Sepsis Mortality in Obese Diabetic Mice
Matthew J. Delano, MD, PhD, University of Michigan, Ann Arbor, MI
Shock Faculty Research Award 2016 Recipient

3:10 PM – 3:25 PM       
A Uniquely-Human Gene Alters the Inflammatory Response to Injury
Theresa W. Chan, MD, University of California, San Diego, CA
Shock Research Investigator Fellowship 2017 Recipient

3:25 PM – 3:40 PM       
Influence of Neutrophil Extracellular Traps on Vascular Permability
Hisatake Mori, MD, Aichi Medical University School of Medicine, Nagakute, Japan
Japan Shock Society Young Investigator Award 2017 Winner

3:40 PM – 3:55 PM       
Integrin and PD-1 Ligand Expression on Circulating Extracellular Vesicles in Systemic Inflammatory Response Syndrome and Sepsis
Eiji Kawamoto, MD, PhD, Mie University Graduate School of Medicine, Tsu-city, Japan
Japan Shock Society Young Investigator Award 2017 Winner

4:15 PM - 6:15 PM
Parallel Session I: The Cellular Basis of Shock
Moderators:
Melanie Scott, MD, PhD, University of Pittsburgh, Pittsburgh, PA
Yoram Vodovotz, PhD, University of Pittsburgh, Pittsburgh, PA

4:15 PM – 4:30 PM         
Platelet Integrin Gene Expression and Function are Upregulated in Sepsis and Associated with Morality
Elizabeth A. Middleton, MD, University of Utah, Salt Lake City, UT
 
4:30 PM – 4:45 PM            
Extracellular (EX) MIR-146a Induces Proinflammatory Respose via TLR7 Sinaling in a Murine Sepsis Model
Sheng Wang, PhD, University of Maryland School of Medicine, Baltimore, MD
 
4:45 PM – 5:00 PM         
The TLR4 Agonist Monophosphoryl Lipid A Mediates Broad Protection Against Infection via Augmenation of Innate Antimicrobial Cell Functions
Liming Luan, PhD, Vanderbilt University Medical Center, Nashville, TN
 
5:00 PM – 5:15 PM           
CIRP Induces Netosis in Lungs during Sepsis
Yasumasa Ode, MD, PhD, The Feinstein Institute for Medical Research, Manhasset, NY
 
5:15 PM – 5:30 PM           
Hepatic Signal Transducer and Activator of Transcriptio-3 (STAT3) Alters the Inflammatory Respose in Obese Mice during Sepsis
Jennifer Kaplan, MD, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
 
5:30 PM – 5:45 PM         
TIGIT Modulates Sepsis-induced Dysregulation in Hosts with Pre-Existing Malignancy
Wenxiao Zhang, MD, Emory University School of Medicine, Atlanta , GA
 
5:45 PM – 6:00 PM              
Sepsis Differentially Impacts Tumor-Specific vs. Bystander T Cells in Mice with Pre-existing Malignancy
Ching-wen Chen, MS, Emory University School of Medicine, Atlanta, GA
 
6:00 PM – 6:15 PM          
MIR-146a Targeting Splenic Macrophages Prevents Sepsis-induced Multiple Organ Injury Including Acute Kidney Injury
Yoshio Funahashi, MD, Nagoya University Graduate School of Medicine, Nagoya, Japan

4:15 PM - 6:15 PM
Parallel Session II: The Physiologic Basis of Shock
Moderators:
Celeste Finnerty, PhD, UTMB/ Shriners Hospitals for Children, Galveston, TX
Samithamby Jeyaseelan, PhD, Louisiana State University, Baton Rouge, LA

4:15 PM – 4:30 PM             
Metformin, Independently of AMPK, Reduces Lipolysis via Protein Phosphatese 2A Activation in Beige Adipose Tissue
Christopher Auger, PhD, Sunnybrook Health Sciences Centre, Toronto, Canada
 
4:30 PM – 4:45 PM          
Increased Platelet MHC I Expression during Severe Sepsis Impairs CD8+ T Cell Responses
Li Guo, MD, PhD, Molecular Medicine Program, University of Utah, Salt Lake City, UT
 
4:45 PM – 5:00 PM        
FLI-1 Induces Pericyte Loss and Microvascular Dysfunction in Murine Sepsis
Pengfei Li, PhD, Medical University of South Carolina, Charleston, SC
 
5:00 PM – 5:15 PM         
A Versitile Nanotrap to Remove Endotoxin and Cytokines for Sepsis Treatment
Juntao Luo, PhD, SUNY Upstate Medical University, Syracuse, NY
 
5:15 PM – 5:30 PM           
Trauma Induced Emergency Hematopoiesis through MyD88-Dependent Production of G-CSF
Isaiah R. Turnbull, MD, PhD, Washington University, St. Louis, MO
 
5:30 PM – 5:45 PM           
Role of Toll-like Receptor Signaling in Sepsis-induced Coagulopathy
Brittney Williams, MD, University of Maryland School of Medicine, Baltimore, MD
 
5:45 PM – 6:00 PM              
Role of Human SP-B Genetic Variants and Sex Difference on Lung Injury Caused by P. Aeruginosa
Jing Zhang, MD, PhD, SUNY Upstate Medical University, Syracuse, NY and Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
 
6:00 PM – 6:15 PM          
HDAC6 Inhibition Blocks LPS-induced STAT Activation and Inflammatory Lung Injury
Xiaoming Zhou, MD, Shengjing Hospital of China Medical University, Shenyang, China and University of Kentucky, Lexington, KY

Monday, June 11, 2018


9:00 AM - 11:00 AM
Plenary Session III: Pillars of Shock Research
Moderator:
David Hackam, MD, PhD, Johns Hopkins University School of Medicine, Baltimore, MD

9:00 AM – 9:45 AM         
Just Say Yes! The Life of a Surgeon-Scientist
Ori Rotstein, MD, St. Michael’s Hospital & University of Toronto, Toronto, Canada
 
9:45 AM – 10:30 AM       
The Complex Immune Response Following a Simple Injury and Repair
Paul Kubes, PhD, Cumming School of Medicine, University of Calgary, Calgary, Canada
 
10:30 AM – 10:45 AM    
Caspase-8 Heterodimerization Regulates Inflammatory Neutrophil Survival in Sepsis
Sahil Gupta, PhD, St. Michael's Hospital & University of Toronto, Toronto, Canada
 
10:45 AM – 11:00 AM    
Hepatocytes Actively Release HMGB1 via Exosomes during Sepsis
Wenbo Li, MD, University of Pittsburgh, Pittsburgh, PA and The Third Xiangya Hospital, Central South University, Changsha, China
 

Tuesday, June 12, 2018

9:00 AM - 11:30 AM
Parallel Session III: Connectivity in Shock
Moderators:
Jennifer Kaplan, MD, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Barbara Sherry, PhD, The Feinstein Institute for Medical Research, Manhasset, NY

9:00 AM – 9:15 AM         
Promotor Polymorphism in AQP5 Gene Associates wih Increased Survival and Decreased Numbers of Monocytic MDSC in Abdominal Sepsis (BY SEPSIS-3)
Vladimir M. Pisarev, MD, PhD, Federal Research and Clinical Center of Intensive Care Medicine, Moscow, Russia
 
9:15 AM – 9:30 AM         
Sepsis is Associated with Reduced Spontaneous Neutrophil Migration Velocity in Human Adults
Steven L. Raymond, MD, University of Florida College of Medicine, Gainesville, FL
 
9:30 AM – 9:45 AM         
Protein Kinase C-delta Inhibition Protects the Brain from Sepsis-Induced Vascular Damage
Yuan Tang, PhD, Temple University, Philadelphia, PA
 
9:45 AM – 10:00 AM       
Isoforms of HMGB1 Activate Neuronal Cells in Vitro and Modulate Pain-Like Behavior in Animals
Huan Yang, PhD, The Feinstein Institute for medical Research, Manhasset, NY
 
10:00 AM – 10:15 AM    
The Acute Effects of Insulin on Whole Body Fuel Metabolism and Skeletal Muscle Bioenergetics in Severely Burned Children
Victoria Rontoyanni, PhD, University of Texas Medical Branch, Galveston, TX
 
10:15 AM – 10:30 AM    
R-107 Attenuates Severity of systemic Microvascularhyper-Permeability in Ovine Septic Shock
Satoshi Fukuda, MD, University of Texas Medical Branch, Galveston, TX
 
10:30 AM – 10:45 AM    
Synthetic Phosphorylated Hexaacyl Disaccharides are Potent TLR4 Agonists and Augment Host Resistance Against Common Nosocomial Pathogens
Antonio Hernandez, MD, Vanderbilt University Medical Center, Nashville, TN
 
10:45 AM – 11:00 AM    
Innate Immune System Monitoring by Spontaneous Neutrophil Migration after Burn Injury
Masayuki Otawara, MD, Massachusetts General Hospital, Harvard Medical School, Boston MA and Kyorin University, Tokyo, Japan
 
11:00 AM – 11:15 AM    
Autophagy Mechanism Atteuates Hepatic Cellular Dysfunction in a Murine Sepsis Model
Eizo Watanabe, MD, PhD, Chiba University, Togane City, Japan
 
11:15 AM – 11:30 AM    
Preoperative Exercise Therapy Protects the Liver from Ischemia-Reperfusion Injury
Hongji Zhang, MD, University of Pittsburgh Medical Center, Pittsburgh, PA and Union Hospital, Huazhong University of Science and Technology, Wuhan, China

9:00 AM - 11:30 AM
Parallel Session IV: Integration in Shock Research
Moderators:
Marc Jeschke, MD, PhD, Sunnybrook Research Institute, Toronto, Canada
Teresa Zimmers, PhD, Indiana University School of Medicine, Indianapolis, IN
 
9:00 AM – 9:15 AM         
ACE2 Modulates Innate Immune Response Against Bacterial Lung Infection
Hongpeng Jia, MD, Johns Hopkins University, Baltimore, MD
 
9:15 AM – 9:30 AM         
Prospective Validation of a Genomic Metric for Use in Clinical Trials with Severe Trauma
Russell B. Hawkins, MD, University of Florida, Gainesville, FL
 
9:30 AM – 9:45 AM         
The RNA Splicosome in Critical Illness: U1-70K as a Potential Therapuetic Target
Sean F. Monaghan, MD, Rhode Island Hospital and Brown University, Providence, RI
 
9:45 AM – 10:00 AM       
Effect of Electrical Vagus Nerve Stimulation on Neurological Outcome in Asphyxial Cardic Arrest Model of Rats
Inwon Park, MD, PhD, Seoul National University Bundang Hospital (SNUBH), Seongnam-si, Republic of Korea
 
10:00 AM – 10:15 AM    
Humanized-mouse Platform for Deciphering Clinically Relevant Differences in the Bone Marrow and Splenic Leukocytes between Lethal and Survivable CLP Sepsis
Tomasz Skirecki, MD, PhD, The Center of Postgraduate Medical Education, Warsaw, Poland
 
10:15 AM – 10:30 AM    
SECTM1A Attenuates Sepsis-induced Impairment of Tissue-resident Macrophage Self-renewal Capacity in Mice
Xingjiang Mu, PhD, University of Cincinnati College of Medicine, Cincinnati, OH
 
10:30 AM – 10:45 AM    
Apoptotic T Cell-Derived Microparticles Containing Sonic Hedgehog Significantly Diminish Endothelial Nitric Oxide Production in Inflammatory via Rho Kinase Pathway
Neha Attal, MS, University of North Carolina, Charlotte, NC
 
10:45 AM – 11:00 AM    
Toll-Like Receptor 7 Deficiency Reduces Acute Kidney Injury and Improves Survival in a Mouse Model of Sepsis
Briana Shimada, PhD, Department of Anesthesiology and Shock Trauma Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD
 
11:00 AM – 11:15 AM    
Optogenetic Stimulation of Cholinergic Neurons in the Dorsal Motor Nucleus Attenuates Endotoxin-Induced Systemic Inflammatory Responses
Adam M. Kressel, MD, The Feinstein Institute for Medical Research and Department of Surgery, Northwell Health, Manhasset, NY

12:30 PM - 1:30 PM
Oral Presentations By Young Investigators
Moderators:
Carrie Sims, MD, PhD, The Trauma Center at Penn, Philadelphia, PA
Co-Moderator to be announced
 
12:30 PM – 12:42 PM     
SECTM1A is Critical for Macrophage Phagocytosis during Polymicrobial Sepsis in Mice
Xingjiang Mu, PhD, University of Cincinnati College of Medicine, Cincinnati, OH
 
12:42 PM – 12:54 PM     
Toll Like Receptor 9 Therapy Reverses the Two-hit Response to Trauma in Mice
Yasutaka Nakahori, MD, Brigham & Women's Hospital/Harvard Medical School, Boston, MA
 
12:54 PM – 1:06 PM       
Splenic Neutrophils May Serve as Primary Responders to Lung Infection during Persisent Inflammation, Immunosuppression and Catabolism Syndrome (PICS)
Leah K. Winer, MD, University of Cincinnati, Cincinnati, OH
 
1:06 PM – 1:18 PM          
Endothelial HSPA12B Plays a Protective Role in Sepsis-induced Mortality by Regulating Innate Immune Responses via Crosstalk between Endothelial Cells and Macrophages
Fei Tu, MS, PhD candidate, East Tennessee State Univfersity, Johnson City, TN
 
1:18 PM – 1:30 PM          
Deformylase Improves Survival in Cecal Litigation Model of Sepsis and Prevents Endothelial Barrier Dysfunction in Trauma-induced Systemic Inflammatory Response syndrome
Patricia Martinez Quinones, MD, Medical College of Georgia at Augusta University, Augusta, GA

1:30 PM - 3:10 PM
Plenary Session IV: Bench to Bedside Translation of Therapeutics – at the Crossroads of Immunity and Host Defence
Moderators:
Philip Efron, MD, University of Florida, Gainesville, FL
Misty Good, MD, Washington University School of Medicine, St. Louis, MO

1:30 PM – 1:55 PM          
Microvascular Endothelial Barrier Injury during Inflammation
Sarah Yuan, MD, PhD, University of South Florida College of Medicine, Tampa, FL
 
1:55 PM – 2:20 PM          
To Kill or be Killed: Neutrophils in Bacterial Pneumosepsis
Jyotika Sharma, PhD, University of North Dakota, Grand Forks, ND
 
2:20 PM – 2:45 PM          
Burn Injury: A Model for Bench to Bedside Translational Therapeutics in the Immunocompromised Patient
Tina L. Palmeri, MD, UC Davis Medical Center, Shriners Hospital for Children, Sacremento, CA
 
2:45 PM – 3:10 PM          
From Bench to Bedside to Bench: Rodent Models and the Critically Ill
Alicia M. Mohr, MD, University of Florida College of Medicine, Gainesville, FL

3:30 PM - 5:30 PM
Master Class Symposium
Moderators:
Laurie Kilpatrick, PhD, Temple University, Philadelphia, PA
Shibani Pati, MD, PhD, Blood Systems Research Institute, San Francisco, CA

3:30 PM – 4:00 PM
Mechanisms, MicroRNAs, and Modulators of the Endotheliopathy of Trauma
Rosemary Kozar, MD, PhD, University of Maryland, Baltimore MD

4:00 PM – 4:30 PM
Leukocyte-Endothelial Cell Interactions in Inflammation
Laurie Kilpatrick, PhD, Temple University, Philadelphia, PA

4:30 PM – 5:00 PM
Assessment of Musculoskeletal Phenotypes in Cell Cultures and Mouse Models of Injury and Chronic Disease
Teresa Zimmers, PhD, Indiana University School of Medicine, Indianapolis, IN

5:00 PM - 5:30 PM
Animal Models in Neonatal Sepsis/Shock Research: From the Bench to the Bedside and Back
Misty Good, MD, Washington University School of Medicine, St. Louis, MO

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