Meetings Program-at-a -Glance

PROGRAM-AT-A-GLANCE
as of 4/3/2017



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SATURDAY, JUNE 3, 2017

1:00 - 3:00 pm Plenary Session I:  Mitochondrial Dysfunction in Shock
  Moderators:  C. Sims, MD, PhD and L. Becker, MD
 
  • C. Sims - Trauma
  • T. Kilbaugh - TBI
  • S. Weiss - Sepsis
  • R. Levy - Non-traumatic Brain Injury
  • C. Auger - Metformin Corrects Hepatic Mitochondrial Abnormalities in a Murine Model of Thermal Trauma
  • V. Rontonyanni - Determinants of Skeletal Muscle Mitochondrial Respiratory Function in Children with Severe           Burns
1:00 - 5:00 pm Poster Presenters must set up their posters
3:30 - 5:30pm Plenary Session II:  Best of the Best:  Top Rated Abstracts Submitted
  Moderators:  P. Wang and T. Billiar, MD
 
  • J. Rincon - Improved Survival in Murine Neonatal Sepsis following Alum Pretreatment is Dependent on Non-             Granulocyte GR1 Positive Myeloid Cells and is Inflammasome-independent
  • X. Zhang - Surfactant Protein D Modulates the Activation and Differentiation of Endogenous Krt5+ Stem Cells             following Lung Injury through Regulation of Notch Signaling Pathway
  • Y. Guo - Interleukin (IL)-15 enables Septic Shock by Maintaining Natural Killer Cell Integrity and Function
  • D. Irimia - Accurate Sepsis Diagnosis from One Droplet of Whole Blood
  • S. Fukuda - Toll-like Receptor-4 Agonist (Monophosphoryl Lipid A) Prevented Onset of Sepsis in Ovine Model of         Cutaneous Burn and Pneumonia
  • M. Delano - Toll-like Receptor 2 and Tumor Necrosis Factor Alpha Induce Acute Kidney Injury through Renal C3         Production during Sepsis
  • C. Chen - Blockade of 2B4 but not PD-1 Mediates Decreased Sepsis Mortality in Animals with Preexisting Malignancy
  • J. Strohl - Sepsis Leads to Impaired Contextual Memory and Abnormal Hippocampal Ensemble Dynamics
5:30 - 6:30pm Presidential Address:  Timothy Billiar, MD
6:30 - 7:30pm Presidential Reception
7:30pm - 9:00pm New Investigators Workshop
   

SUNDAY, JUNE 4, 2017

7:00 - 9:00am Continental Breakfast & Poster Session I
9:00 - 11:30am Plenary Session III:  Building a Better Mousetrap - Modeling Sepsis
  Moderators:  D. Remick and C. Coopersmith
 
  • C. Seymour - How Clinical Studies on Sepsis are Designed
  • P. Efron - Current Sepsis Models - The Good, the Bad and the Ugly
  • C. Deutschman - Potential Endpoints: Mortality vs. Immunologic Changes vs. Organ Dysfunction
  • C. Coopersmith - What Can be Translated and What Cannot
  • D. Remick - The Model Grant Proposal
  • M. Osuchowski - The Wiggers: Bernard Conference - Evidence Driven, Expert Opinion on an Improved Model
11:30 - 12:30pm KEYNOTE ADDRESS: Chad Bouton
12:30 - 1:30pm Lunch
12:30 - 1:30pm Luncheon Seminar:  Academic and Industrial Job Skills
1:00 - 5:00pm Poster Presenters must set up their posters
1:30 - 3:00pm New Investigator Competition
  Moderator:  W. Yang, PhD
 
  • P. Kim - Metformin Exerts Beneficial Effects in Hemorrhagic Shock in an AMPKa1-independent Manner
  • Y. Kim - Endocytosis of Red Blood Cell Microparticals by Endothelial Cells Mediated by Rab5
  • J. McGinn - The Protective Effect of a Short Peptide derived from Cold-inducible Ribonucleic Acid-binding Protein in   Renal Ischemia Reperfusion Injury
  • L. Schimunek - A Single Nucleotide Polymorphism in MPPED2 is Associated with Increased Requirement for             Mechanical Ventilation and Mortality in Trauma
  • J. Stortz - Biomarker Evidence for Persistent Immune Suppression in Patients who Develop Chronic Critical Illness     after Sepsis
3:00 - 4:00pm Research Fellowship Recipient Presentations
  Moderator:  W. Yang, PhD
 
  • P. Lu - Deletion of the Endotoxin Receptor Toll-like Receptor 4 from Intestinal Epithelial Cells leads to Metabolic           Syndrome in Mice
  • Q. Sun - Cardiolipin Functions as Intracellular DAMP to Activate Caspase 11 after Hemorrhagic Shock
  • L. Hendricks - Xenogeneic Compatibility of Human Blood and Blood derived Components in Preclinical Animal            Models
  • N. Nishizawa - PGE2 derived from Microsomal Prostaglandin E Synthase-1 (Mpges-1) induces Hepatic                        Ischemia/Reperfusion Injury through EP4 Receptor Signaling
4:30 - 6:30pm Parallel Session I:  Traumatic Brain Injury
  Moderators:  R. Kozar and C. Wade
 
  • J. Dong, Microparticles and TBI
  • G. Fiskum, Hyperoxia and TBI
  • M. Goodman, Platelet Dysfunction in TBI
  • C. Cox, TBI and Stem Cells
  • H. Makinde - Nonclassical Monocytes are Required for Neutrophil Recruitment in Traumatic Brain Injury
  • D. Liu - Computational Analysis Supports an Early Role of Lymphoid Associated Cytokines in Traumatic Brain Injury      Survivors
4:30 - 6:30pm Parallel Session II: Immunology and Sepsis Selected Abstracts
 
  • D. Pang - Cytotoxin Cerebral Edema is Correlated with Microglial Activation in a Mouse Model of Sepsis
  • K. Ramonell - Pre-existing Malignancy increases the Co-expression of TIGIT and PD-1 on Activated CD44HI CD4+   T Cells in Septic Mice
  • M. Zhou - The Protective Role of Human Ghrelin in Sepsis: Improvement of CD4 T Cell Proliferation
  • X. Li - A Proof of Concept Study that supports the used of Precision Medicine Approach for Glucocorticoid Sepsis       Therapy
  • J. Xie - Sepsis Erodes CD8+ memory T Cell Protective Immunity against an EBV Homolog in a 2B4-dependent           Manner
  • M. Starr - Pathological Role of Viceral White Adipose Tissue in Development of Severe Acute Pancreatitis in Aged       Mice
  • N. Klingensmith - Improved Survival in Septic JAM-A-/- Mice and Intestinal Microbiome-Immune Interaction 
6:30 - 7:00pm Reception
7:30 - 10:00pm Dinner - New Investigator Competition and Travel Awards Ceremony
   

MONDAY, JUNE 5, 2017

6:00 - 7:00am Presidential Fun Run
7:00 - 9:00am Continental Breakfast & Poster Session II
9:00 - 11:00am Plenary Session IV: Carbon Monoxide and Hydrogen Sulfide in Critical Illness
  Moderator:  C. Szabo and L. Otterbein
 
  • B. Zuckerbraun - Role of CO in Critical Illness
  • S. Dore - Potential Neuroprotective Role of CO in the Injured Brain
  • C. Szabo - Role of H2S in Critical Illness
  • T. Toliver-Kinsky - Bacterial Hydrogen Sulfide Confers Resistance to the Immune System
  • M. Ferlito - Hydrogen Sulfide induces Autophagy in Mouse and Human Macrophages 
12:00 - 1:00pm Shock Society Business Meeting
1:00 - 5:00pm Poster Presenters must set up their posters
1:00pm FREE AFTERNOON and EVENING
   

TUESDAY, JUNE 6, 2017

7:00 - 9:00am Continental Breakfast & Poster Session III
9:00 - 11:30am Parallel Session III: Inflammation and Injury in Children
  Moderators:  D. Hackam and J. Prince
 
  • D. Hackam – Early Immune Development in Neonatal Sepsis
  • J. Prince – Neonatal Sepsis - Pathogenesis and Mechanisms
  • K. Mollen – Pediatric IBD and the Mitochondrial Response
  • H. Jia - Neoonatal Systemic Inflammation and the Effect on the Developing Lung
  • S. Raymond - Neutrophil Function and Transcriptomics in Term and Preterm Neonates
  • A. Bolognese - The Protective effect of Glycolipid Stimulation in Neonatal Sepsis is Mediated by the MHC-like             Molecule CD1D
  • J. Wynn -  Interferon Signaling and Lipocalin-2 are Prominent in the Early Transcriptomic Response in Murine Cerebral Cortex of Septic Neonatal Mice
9:00 - 11:30am Parallel Session IV:  Lung Injury
  Moderators:  L. Kilpatrick and L. Ware
 
  • M. Kiani - Modeling PKC-delta Regulation of Neutrophil Endothelial Interactions with a Novel Microfluidics Device
  • J. Lomas-Neira - Targeting the Pulmonary Endothelial as a Therapeutic Approach for Treating Indirect Acute             Lung Injury
  • L. Ware - Molecular Phenotyping to Reduce Heterogeneity in ARDS
  • M. Matthay - Progress in Mesenchymal Stem Cell Therapy in Acute Lung Injury
  • S. Madathilparambil - Water-soluble Curcumin Complex Administration Reduces Severity of Lethal Pneumonia
  • H. Fan - Microrna 887 and 15A are Differentially Expressed in ARDS and Alter Disease-relevant Gene Expression
  • S. Kikuchi - Genetic Deficiency of AMP-activated Protein Kinase Alpha1 Worsens Lung Injury during Polymicrobial     Sepsis
11:30 - 12:30pm Lunch
12:30 - 2:00pm Plenary Session V:  Best of the Best 2
  Moderators:  M. Jeschke and T. Billiar
 
  • C. Valentine - Early Blockade of PD-L1 increased Mortality in Sepsis
  • J. Bohannon - Treatment with the TLR4 Agonist Monophosphoryl Lipid A Protects Mice against Severe                     Staphylococcus Aureus infection via Augmentation of Innate Antimicrobial Cell Functions
  • A. Sharma - Inhibition of Beta-Catenin/TCF Signaling Mitigates Sepsis-induced Organ Injury
  • L. Zou - Circulating Exosome-associated Mirnas are Proinflammatory in Sepsis
12:00 - 1:30pm Plenary Session VI: Innovative Approaches to Shock Research
  Moderators:  C. Deutschman and TBD
 
  • M. KianiMicrovascular Network on a Chip
  • T. KilbaughMeasuring Mitochondrial Function
  • M. CeredaLung Imaging
  • P. HuertaCognitive Function
  • C. Sodi Genetic Models in Pediatric Sepsis
1:30 - 3:00pm Parallel Session VI: Sepsis Survivors – The Next Big Thing
  Moderators:  B. Sherry and TBD
 
  • D. Gaieski - Sepsis Survivors – The Clinical Problem
  • J. Strohl - Cognitive Dysfunction
  • S. Brakenridge - Persistent Hyper-metabolism
  • S. Chavan - White Cell Function and Cytokine Patterns in Sepsis – Acute vs. Chronic
  • A. Steele - Mitochondrial Damage and Dysfunction in Skeletal Muscle of Middle-aged Murine Sepsis Survivors
  • T. Ozment - Donepezil increases Survival in CLP Sepsis but Persistent Splenic Pathology and Bacterial Infection         Remain in 28-day Survivors
6:00 – 7:00 pm Reception
7:00 – 9:00pm Dinner – Scientific Achievement and Service Awards Ceremony