The 47th Annual Conference On Shock

June 1-4, 2024
PGA National Resort
Palm Beach Gardens, Florida

Submit an abstract to present at this year's conference today! Click here for more details.

Hotel & Travel Information

Conference Registration

Poster Presenter Guidelines

SHOCK 2024 Poster Session Schedule-All Sessions


Conference Schedule

Bridging the Gap: Basic Science to Translation in Sepsis and Injury

Saturday, June 1, 2024

Setting Event
1:00 PM – 1:05 PM General Session Welcome and Introduction: Dr. Melanie Scott PhD, University of Pittsburgh
1:05 PM – 3:05 PM

Moderators
Sean Monaghan MD, Brown University
John Lyons MD, Emory University

Plenary Session I – Immunologic Perspectives in Sepsis

Invited Speakers

  • 1:05 PM – 1:25 PMJulia Bohannon Ph.D., Vanderbilt University, Trained Immunity as a Strategy for Preventing Infection and Sepsis after Burn Injury
  • 1:25 PM – 1:45 PMSean Monaghan MD, Brown University, RNA Biology in Sepsis
  • 1:45 PM – 2:05 PMJohn Lyons MD, Emory University, Cell Death Proteins as Mediators of the Host Response in Sepsis
  • 2:05 PM – 2:25 PMVidula Vachharajani MD, Cleveland Clinic, Immune Response Transition During Sepsis Progression
  • 2:25 PM – 2:45 PMScott Brakenridge MD, University of Washington, Biomarkers, Phenotypes & Endotypes in Sepsis: Concepts, Definitions & Future Directions
2:45 PM – 4:00 PM

Moderators
Scott Brakenridge MD, University of Washington

Lucy Kornblith MD, University of California San Francisco  

Plenary Session II – Best of the Best: Top-Rated Abstracts

Oral Abstracts

  • 2:45 PM – 3:00 PM: Zhangying Chen, Northwestern University, ANTI-CD49D ANTIBODY TREATMENT REJUVENATED EXHAUSTED CD8+ T CELLS IN AGED MICE AFTER TRAUMATIC BRAIN INJURY (Abstract 4082825)
  • 3:00 PM – 3:15 PM: Stephanie Patterson, Monroe Carell Junior Children's Hospital at Vanderbilt, DELAYED GASTROINTESTINAL MICROBIAL DIVERSIFICATION IN HOSPITALIZED INFANTS WITH CONGENITAL HEART DISEASE (Abstract 4076530)
  • 3:15 PM – 3:30 PM: Alexandria Byskosh, Brigham and Women’s Hospital UNTAMED IMMUNITY: USING "DIRTY" MICE AS A NEW PARADIGM FOR TRANSLATABLE TRAUMA IMMUNOLOGY RESEARCH (Abstract 4079297)
  • 3:30 PM – 3:45 PM: Kenneth Meza Monga, University of Colorado, A NOVEL APPROACH TO BURN-INDUCED CARDIAC DAMAGE: THE ROLE OF HEPATIC FGF21 IN AGED MICE (Abstract 4080500)
  • 3:45 PM – 4:00 PMMatt Stier, Vanderbilt University Medical Center

    METABOLIC REWIRING OF THE CD4 T CELL COMPARTMENT IN HUMAN CRITICAL ILLNESS AND SEVERE SEPSIS (Abstract 4080810)

4:00 PM – 4:15 PM Refreshment Break
4:15 PM – 5:20 PM

Moderators
Dan Remick MD, Boston University School of Medicine
Julia Bohannon Ph.D., Vanderbilt University Medical

Plenary Session III – Shock Journal: State of the Journal & Oral Presentations of Most Downloaded Papers

Invited Speakers

  • 4:15 PM – 4:35 PM: Dan Remick MD,  Boston University School of Medicine State of the Journal
  • 4:35 PM – 4:45 PMAhmed Shible, PharmD, University of North Carolina Health, Evaluation of hydrocortisone, vitamin C, and thiamine for the treatment of septic shock: A randomized controlled trial (THE HYVITS TRIAL)
  • 4:45 PM – 4:55 PMChase Salmon, Indiana University, Evaluation of tranexamic acid and calcium chloride in major traumas in a prehospital setting: A narrative review
  • 4:55 PM – 5:05 PMTrine Lynghaug, The Artic University of Norway, How should tranexamic acid be administered in hemorrhagic shock? Continuous serum concentrations in a swine model. 
  • 5:05 PM – 5:15 PMMarc Maegele, MD Cologne-Merheim Medical Center, New insights into the pathophysiology of trauma and hemorrhage
5:30 PM – 6:30 PM Presidential Address – Philip Efron, MD
University of Florida-Gainesville
Topic/Title: Success in Academic Research through Science Fiction Cinema
6:30 PM – 7:30 PM Welcome Reception – New Members Welcome
7:30 PM – 9:00 PM Mentoring Workshop Dinner
Sarah Yuan MD PhD, University of South Florida
Elizabeth Kovacs PhD, University of Colorado

 

 

Sunday, June 2, 2024

Setting Event
7:30 AM – 9:00 AM Poster Session I – Exhibit Hall
Continental Breakfast
9:00 AM – 10:30 AM

Moderators
Tyler Loftus MD, University of Florida-Gainesville

Plenary Session IV – Advancements in Precision Medicine in Trauma and Sepsis

Invited Speakers

  • 9:00 AM – 9:20 AMJeff Choi MD MSc, Stanford University, AI and Clinical Decision Support Models: Pitfalls Overshadowing Promises
  • 9:20 AM – 9:40 AMAmelia Maiga MD, Vanderbilt University
    AI in Prognostication for Critically Injured Patients
  • 9:40 AM – 10:00 AMGabriel Brat MD, Beth Israel Deaconess Medical Center
    Integrating Human Intuition with AI Modeling

Oral Abstracts

  • 10:00 AM – 10:10 AM: Jeremy Balch, University of Florida, TRANSCRIPTOMIC EVIDENCE THAT CRITICAL ILLNESS INDUCES AN EARLY EXPANSION OF MULTIPLE MYELOID IMMUNE SUPPRESSIVE SUBSETS (Abstract 4082825)
  • 10:10 AM – 10:20 AM: Zander Tyler, University of South Florida, PREDICTING UNPLANNED TRAUMA ICU ADMISSIONS USING INTERPRETABLE MACHINE LEARNING (Abstract 4076569)
  • 10:20 AM – 10:30 AM: Angelos Vasilopoulos, Loyola University, CLINICAL VARIABLE-BASED PREDICTION OF ACUTE RESPIRATORY DISTRESS SYNDROME ENDOTYPES (Abstract 4072286)
10:30 AM – 10:50 AM Refreshment Break
11:00 AM – 12:00 PM Keynote Address – Joe G.N. ‘Skip’ Garcia MD
UF Scripps Institute Biomedical Innovation & Technology
Topic/Title: “DAMPening Inflammatory Injuries in Critical Illnesses via Innate Immunity Targeting”
12:00 PM – 1:00 PM Boxed Lunch
12:10 PM – 1:10 PM

Moderators
Juan Idrovo MD, University of Colorado

Young Investigators – Oral Presentations By and For Young Investigators
(Young Investigators only – bring lunch into the room)

Young Investigators

  • 12:10 PM – 12:22 PM: Seibi Kobara, Emory University, ALTERED SPHINGOLIPID BIOSYNTHESIS DURING ARDS WAS ASSOCIATED WITH PHYSICAL IMPAIRMENT AT HOSPITAL DISCHARGE IN SURGICAL ICU PATIENTS (Abstract 4074945)
  • 12:22 PM – 12:34 PM: Ikechukwu Jacob, SUNY Upstate Medical Center, SURVIVING DEADLY LUNG INFECTIONS: DIFFERENTIAL IMMUNOMODULATORY ROLES OF HUMAN SP-A VARIANTS IN RESPONSE TO SARS-COV-2 INFECTION (Abstract 4082887)
  • 12:34 PM – 12:46 PM: Arielle Ayotte, University of Florida, PLASMA EXTRACELLULAR VESICLE MIRNA CARGO AND RESULTANT MACROPHAGE IMMUNE REPROGRAMMING ARE ASSOCIATED WITH POOR OUTCOMES AFTER SEPSIS (Abstract 4082887)
  • 12:46 PM – 12:58 PM: Ozel Mehves, University of Pittsburgh Medical Center, DOGMA-SEQUENCING ANALYSIS OF AGE-DEPENDENT RESPONSE TO MAJOR ELECTIVE SURGERY REVEALED A PRO-INFLAMMATORY AND DYSREGULATED SUBSET OF CD14+ MONOCYTES IN AGED PATIENTS AFTER SURGERY (Abstract 4083731)
  • 12:58 PM – 1:10 PM: Ava Mokhtari, The University of Texas Health Science Center at Houston, TREATMENT WITH HEPARAN SULFATE ANTAGONIST, SURFEN, TO BLOCK ENDOTHELIAL-ANTITHROMBIN INTERACTIONS, MITIGATES THE PULMONARY PROTECTIVE EFFECTS OF PLASMA AFTER HEMORRHAGIC SHOCK (Abstract 4082198)
1:20 PM – 2:35 PM

Moderators
Myung Park MD, Mayo Clinic
Lauren Moffatt PhD, MedStar Health Research Institute

New Investigators – New Investigator Competition

New Investigators

  • 1:20 PM – 1:35 PM: Matthew Alves, University of Florida, MULTIMODAL NUCLEAR FACTOR-ERYTHOID-2-RELATED FACTOR (NRF2) THERAPY IN THE CONTEXT OF MAMMALIAN TARGET OF RAPAMYCIN (MTOR) INHIBITION REGULATES IMMUNE REPROGRAMMING IN RESPONSE TO INFECTION EARLY AFTER BURN AND INHALATION INJURY (Abstract 4083092)
  • 1:35 PM – 1:50 PM: Joseph Krocker, University of Texas Health Science Center at Houston, CIRCULATING TRPM4 AND SUR1 AND CLINICAL OUTCOME FOLLOWING TRAUMATIC BRAIN INJURY (Abstract 4083558)
  • 1:50 PM – 2:05 PM: Grace Bonson, University of Vermont, ENDOTHELIAL-SPECIFIC ABLATION OF THE SCRAMBLASE TMEM16F REDUCES IN VIVO CLOT FORMATION IN MICE (Abstract 4081204)
  • 2:05 PM – 2:20 PM: Meagan Kingren, University of Arkansas, HOUSING TEMPERATURE ALTERS BURN-INDUCED HYPERMETABOLISM IN MICE (Abstract 4077893)
  • 2:20 PM – 2:35 PM: Russell Hollis, Northwell Health Feinstein Institutes for Medical Research, A NOVEL OPSONIC EXTRACELLULAR CIRP INHIBITOR MOP3 ALLEVIATES GUT ISCHEMIA/REPERFUSION INJURY (Abstract 4076905)
2:45 PM – 3:45 PM

Moderators
Myung Park MD, Mayo Clinic
Lauren Moffatt PhD, MedStar Health Research Institute

Research Awards – Research Fellowship Recipient Presentations

Awardee Speakers

  • 2:45 PM – 3:00 PM:  Faculty Research Award Recipient
    Patricia DeAssis University of Michigan ([email protected])
    Metabolic reprogramming of CD4 T cells: Implications for post-sepsis immunosuppression

  • 3:00 PM – 3:15 PM: Research Investigator Fellowship Recipient
    Min Fan ([email protected])  POSTPONED TO 2025
    Novel role of lactate in MDSC-mediated immunosuppression in sepsis

  • 3:00 PM – 3:15 PM: Japan Shock Society Presidents Award
    Tadashi Matsuoka MD PhD, Keio University ([email protected])
    Resuscitative Endovascular Balloon Occlusion of the Aorta with downstream intra-aortic irrigation using hydrogen-containing solution mitigates ischemic injury in a swine hemorrhagic shock with liver injury

  • 3:15 PM – 3:30 PM: Japan Shock Society Chairmans Award
    Kensuke Nakamura ([email protected])
    Vasopressin loading for refractory septic shock (VALOR) study: A prospective observational study

3:30 PM – 4:00 PM Refreshment Break
4:00 PM – 5:30 PM

Moderators
Linda Sousse PhD MBA, Institute for Extracorporeal Life Support
Jeff DellaVolpe MD MPH, Institute for Extracorporeal Life Support

Parallel Session 1 – Addressing the Pathophysiology of Severe Lung Injury: A Translational Approach with ECMO

Invited Speakers

  • 4:00 PM – 4:20 PMLinda Sousse PhD MBA, Institute for Extracorporeal Life Support, Pathophysiology of respiratory ECMO
  • 4:20 PM – 4:40 PMLorraine Ware MD, Vanderbilt University Medical Center
    ARDS and ECMO
  • 4:40 PM – 5:00 PMMarc Maybauer MD PhD, University of Florida, Veno-Pulmonary ECMO-A new era in acute mechanical circulatory support
  • 5:00 PM – 5:20 PMEddy Fan MD PhD, Toronto General Hospital Research Institute, Clinical presentation in V-V-ECMO

Oral Abstracts

  • 5:20 PM – 5:30 PM: Raleigh Garner, National Jewish Health, COAGULATION FACTOR XIII-A AUGMENTS INFLAMMATION AND IS PRODUCED BY MONOCYTE-DERIVED MACROPHAGES DURING ACUTE LUNG INJURY (Abstract 4079376)

4:00 PM – 5:30 PM

Moderators
Charles Wade PhD, the University of Texas Health Science Center at Houston
Chris Barrett MD, University of Nebraska Medical Center

Parallel Session 2 – Hemorrhagic Shock and Clinical Applications

Invited Speakers

  • 4:00 PM – 4:20 PMMartin Schreiber MD, Oregon Health & Sciences University
    Resuscitation 2024 and the Future
  • 4:20 PM – 4:40 PMChris Barrett MD, University of Nebraska Medical Center
    Novel approach to diagnosis of fibrinolytic perturbations in trauma and critical illness
  • 4:40 PM – 5:00 PMJonathan Meizoso MD MSPH, University of Miami
    Bleeding and Clotting: Updates in Damage Control Resuscitation

Oral Abstracts

  • 5:00 PM – 5:10 PM: Alan Weaver, US Army Institute of Surgical Research, INVESTIGATION INTO THE POTENTIAL ROLES OF COAGULOPATHY AND ENDOTHELIOPATHY ON SURVIVAL IN A SWINE MODEL OF UNCONTROLLED HEMORRHAGE (Abstract 4079016)
  • 5:10 PM – 5:20 PM: Joud Mulla, University of Pittsburgh, INVESTIGATING CASPASE-11 AND GASDERMIND IN INFLAMMATORY RESPONSES AND COAGULOPATHY POST-POLYTRAUMA (Abstract 4083489)
  • 5:20 PM – 5:30 PM: Boyang Ren, University of Maryland, IDENTIFYING PLASMA MICRO-RNA BIOMARKERS IN TRAUMA PATIENTS (Abstract 4076194)
6:00 PM – 8:00 PM

Moderator
Vanessa Nomellini MD PhD, University of Texas Southwestern

Xiaoli Zhao PhD, Program Director, NIGMS

Demystifying NIH Application Session

  • Elizabeth Kovacs, Ph.D., University of Colorado, Which grant is right for me, and what is the NIH review process?
  •  Rosemary Kozar MD PhD, What goes into the Personal Statement?
  •  Tim Billiar MD, University of Pittsburgh, Tips and tricks to writing highly fundable applications
  • Judith Hellman MD, University of California San Francisco, Responding to the summary statement

 


 

Monday, June 3, 2024

Setting Event
7:30 AM – 9:00 AM Continental Breakfast
7:30 AM – 9:00 AM Poster Session II
9:00 AM – 10:30 AM

Moderators
Judith Hellman MD, University of California, San Francisco

Todd Constantini MD PhD University of California San Diego

Plenary Session V – The Nervous System as a Target and Regulator of Sepsis and Critical Illness

Invited Speakers

  • 9:00 AM – 9:20 AMCliff Deutschman MD, Feinstein Institute
    Orexinergic modulation of inflammation and organ dysfunction/injury
  • 9:20 AM – 9:40 AMLuis Ulloa PhD, Duke University
    The autonomic nervous system in sepsis and injury
  • 9:40 AM – 10:00 AMRaj Aneja MD, University of Pittsburgh
    Sepsis-associated brain injury: Understanding the role of SUR1-TRPM4

Oral Abstracts

  • 10:00 AM – 10:10 AM: Quan Vo, University of Florida, SEPSIS INDUCES PERSISTENT SEX-DIMORPHIC IMMUNE ACTIVATION AND EXACERBATES AMYLOID β PATHOLOGY IN AN AD MOUSE MODEL (Abstract 4075844)
  • 10:10 AM – 10:20 AM: Huan Yang, Northwell Health Feinstein Institutes for Medical Research, ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR-DEPENDENT SIGNALING REGULATES NEURONAL HMGB1 RELEASE (Abstract 4078843)
  • 10:20 AM – 10:30 AM: Ayman Youssef, Duke Medicine, VAGAL STIMULATION RESOLVES COLITIS THROUGH THE DIFFERENTIAL REGULATION OF SUMO ISOFORMS (Abstract 4083707)
10:30 AM – 10:45 AM Refreshment Break
10:45 AM – 12:15 PM

Moderators
Wendy Walker PhD, Mercer University
Elisabetta Liverani PhD, North Dakota State University

Plenary Session VI – DEI: Disparities and Inequities in Shock, Trauma, and Sepsis Research

Invited Speakers

  • 10:45 AM – 11:05 AMWenjun Martini PhD, US Army Institute of Surgical Research, Promoting DEIA through the awareness of its positivity and productivity
  • 11:05 AM – 11:25 AMElisabetta Liverani PhD, North Dakota State University, Enhancing DEIA in science and medicine through faculty hiring and retention practices
  • 11:25 AM – 11:45 AMWendy Walker PhD, Mercer University, Supporting our diverse mentees
  • 11:45 AM – 12:05 PMPatricia De Assis PhD, University of Michigan, Enhancing DEIA in the Shock Society by increasing the visibility of individuals from underrepresented groups

Oral Abstracts

  • 12:05 PM – 12:15 PM: Christina Schwenk, Technical University of Munich, School of Medicine and Health, SPICES TO COMBAT SEPSIS – CURCUMIN PIPERIN COMBINATION INCREASES THE SURVIVAL RATE IN A TWO-HIT-TRAUMA MODEL (Abstract 4078186)
12:15 PM – 1:15 PM SHOCK Society Member Meeting
1:30 PM – 3:00 PM Strategic Planning Committee: By Invitation Only
1:30 PM – 2:15 PM Publications Committee: By Invitation Only
1:30 PM – 2:15 PM Awards & Honors Committee: By Invitation Only
3:15 PM Free Afternoon and Evening

 


 

Tuesday, June 4, 2024

Setting Event
7:00 AM – 8:00 AM Diversity
7:00 AM – 8:00 AM Finance
7:00 AM – 8:00 AM International
7:00 AM – 8:00 AM Lab Animal Issues
7:00 AM – 8:00 AM Scientific Program 2024 & 2025
7:00 AM – 5:00 PM Speaker Ready Room
7:00 AM – 5:30 PM Registration Open
7:00 AM – 11:45 PM Staff Office
7:00 AM – 11:45 PM Storage (AV)
7:30 AM – 9:00 AM Continental Breakfast
7:30 AM – 9:00 AM Exhibit Hall
7:30 AM – 9:00 AM Poster Session III
9:00 AM – 10:30 AM

Moderators
Jeff DellaVolpe MD MPH, Institute for Extracorporeal Life Support
Linda Sousse PhD MBA, Institute for Extracorporeal Life Support

Parallel Session 1 – Cardiogenic Shock: The Next Frontier for the Shock Society

Invited Speakers

  • 9:00 AM – 9:20 AMJeff DellaVolpe MD MPH, Institute for Extracorporeal Life Support, Cardiogenic Shock Mechanisms
  • 9:20 AM – 9:50 AMVedran Premuzic MD PhD, University Hospital Centre Zagreb, Blood purification in ECMO ($$)
  • 9:50 AM – 10:10 AMPerenlei Enkhbaatar MD PhD, University of Texas Medical Branch, Anticoagulation as an adverse event in an ECMO animal model
  • 10:10 AM – 10:30 AMJason Bartos MD PhD, University of Minnesota, eCPR in ECMO ($$)
9:00 AM – 10:30 AM

Moderators
Eric Schmidt MD, Massachusetts General Hospital

Hunter Moore MD, University of Colorado

Parallel Session 2 – Microvascular Dysfunction in Sepsis and Injury

Invited Speakers

  • 9:00 AM – 9:20 AM
    Amily Guo MD PhD, University of Washington, Platelet interactions with CD8+ T cells in sepsis
  • 9:20 AM – 9:40 AM: Eric Schmidt MD, Massachusetts General Hospital, Using a randomized controlled trial to study glycocalyx degradation during human sepsis

Oral Abstracts

  • 9:40 AM – 9:50 AM: Adam Novak, SUNY Upstate Medical University, IMSC-DERIVED EXTRACELLULAR VESICLES ATTENUATE THE INFLAMMATORY RESPONSE IN SEPSIS (Abstract 4079477)
  • 9:50 AM – 10:00 AM: Marissa Pokharel, Florida International University, INFLAMMATORY LUNG INJURY IS ASSOCIATED WITH ENDOTHELIAL CELL MITOCHONDRIAL FISSION (Abstract 4083967)
  • 10:00 AM – 10:10 AM: Robert Richter, The University of Alabama at Birmingham, TRAUMA PROMOTES HEPARAN SULFATE MODIFICATIONS AND CLEAVAGE THAT DISRUPTS HOMEOSTATIC ENDOTHELIAL CELL GENE EXPRESSION (Abstract 4083969)
  • 10:10 AM – 10:20 AM: Feng Wu, University of Maryland, FIBRINOGEN BASED RESUSCITATION MITIGATES LUNG HYPERPERMEABILTY AND ENDOTHELIOPATHY AND RESTORES IMMUNITY IN MICE WITH BACTERIAL PNEUMONIA AFTER HEMORRHAGIC SHOCK (Abstract 4076568)
  • 10:20 AM – 10:30 AM: Desiree Pinto, MedStar Georgetown University Hospital, FIBRINOLYTIC ACTIVATION IS ASSOCIATED WITH MORTALITY AND EARLY ABNORMAL FIBRINOLYTIC PHENOTYPES AFTER BURN INJURY (Abstract 4083467)
10:30 AM – 10:45 AM Refreshment Break
10:45AM – 12:15PM

Moderators
Philip Efron MD
Melanie Scott MD PhD

Plenary Session VII – An Update on NIH and DOD Research Priorities and Opportunities for Trauma, Sepsis, and Burns

Invited Speakers

  • 10:45 AM – 11:05 AM: (PRERECORDED) Guofei Zhou, PhD - Program Director, NHLBI Division of Lung Diseases (DLD)
    NHLBI Research Priorities and Directions in Acute Lung Injury and ARDS
  • 11:05 AM – 11:30 AM:  Xiaoli Zhao, PhD - Program Director, NIGMS
    NIGMS Research Opportunities and Updates  
  • 11:30 AM – 11:55 PM:  Sandy Snyder, MSN, RN, CCRN-K – Program Manager Military Burn Research Program and Defense Medical Research Program-CDMRP
    DOD Research Priorities and Directions
  • 11:55 PM – 12:15 PM: Q&A
12:15 PM – 1:00 PM Boxed Lunch
1:00 PM – 3:00 PM

Moderators
Tony Pusateri PhD, U.S. Army Institute of Surgical Research

Jeffery W. Shupp MD, Medstar Washington Hospital Center

Plenary Session VIII – Acute Burn Resuscitation

Invited Speakers

  • 1:00 PM – 1:20 PM: John C. Kubasiak MD, Loyola University
    Current Clinical Practice on Acute Burn Resuscitation
  • 1:20 PM – 1:40 PM: Anthony E. Pusateri PhD, U.S. Army Institute of Surgical Research, Acute Fibrinolytic and Endothelial Dysfunction after Burn Injury
  • 1:40 PM – 2:00 PM: Myung S. Park MD MS, Mayo Clinic, Acute Burn-Induced Coagulopathy
  • 2:00 PM – 2:20 PM: Lauren T. Moffatt PhD, Medstar Washington Hospital Center
    Acute Inflammatory Response to Burn Injury
  • 2:20 PM – 2:40 PM: Jeffrey W. Shupp MD, Medstar Washington Hospital Center
    Plasma-inclusive Resuscitation of Burn Patients

Oral Abstracts

  • 2:40 PM – 2:50 PM: Mary Grace Murray, Loyola University, PROBIOTIC AKKERMANSIA MUCINPHILA IN BURN INJURY AND ALCOHOL INTOXICATION (Abstract 4069298)
  • 2:50 PM – 3:00 PM: Denise Hernandez, University of Florida, HUMAN MESENCHYMAL STEM CELL EXTRACELLULAR VESICLES REPROGRAM IMMUNE SIGNALING PATHWAYS IN BURN PATIENT IMMUNE CELLS (4082894)
3:00 PM – 4:30 PM

Moderators
Joseph Jeevendra Martyn MD, Massachusetts General Research Institute
Marc Jeschke MD PhD, Health Sciences McMaster University

Parallel Session 5 – Myology and Catabolism in Skeletal Muscle

Invited Speakers

  • 3:00 PM – 3:20 PMShingo Yasuhara MD PhD, Massachusetts General Research Institute, Defective quality control system of mitochondria in critical illnesses – a potential new therapeutic target
  • 3:20 PM – 3:40 PMCraig Porter PhD, University of Arkansas for Medical Sciences, Burn-induced muscle wasting: current understanding and future research opportunities
  • 3:40 PM – 4:00 PMHiroshi Saito PhD, University of Kentucky, Inflammation, wasting/atrophy, and mitochondria dysfunction
  • 4:00 PM – 4:20 PMJoseph Jeevendra Martyn MD, Massachusetts General Research Institute, Motor neuron, microglia, and muscle crosstalk in muscle wasting of burns

Oral Abstracts

  • 4:20 PM – 4:30 PM: Evan Barrios, University of Florida, SEX-SPECIFIC DIFFERENCES IN HUMAN MYELOID-DERIVED SUPPRESSOR CELL MITOCHONDRIAL METABOLISM AFTER SEPSIS (Abstract 4083804)

3:00 PM – 4:30 PM

Moderators
Jennifer Kaplan MD, Cincinnati Children’s Hospital
Marlene Starr PhD, University of Kentucky

Parallel Session 6 – Mechanisms of Organ Dysfunction Following Injury and Sepsis

Invited Speakers

  • 3:00 PM – 3:20 PMMihir Atreya MD MPH, Cincinnati Children’s Hospital Medical Center, Scope of human induced pluripotent stem cells in critical illness research
  • 3:20 PM – 3:40 PMMathias Majetschak MD PhD, University of South Florida, Cross-talk between stress and immunity: Roles of chemokine receptor – vasopressor receptor hetero-oligomers
  • 3:40 PM – 4:00 PMAndrew Lautz MD, Cincinnati Children’s Hospital Medical Center, Human induced pluripotent stem cells to understand cardiomyocyte dysfunction in sepsis

Oral Abstracts

  • 4:00 PM – 4:10 PM: Satoshi Yamaga, The Feinstein Institutes for Medical Research, EXPOSURE TO RADIATION IMPAIRS MACROPHAGE BACTERIAL PHAGOCYTOSIS VIA ECIRP (Abstract 4073675)
  • 4:10 PM – 4:20 PM: Marlene Starr, University of Kentucky, CIRCULATING LIPIDS MAY PROVIDE A SURVIVAL BENEFIT IN THE OBESE WITH SEPSIS (Abstract 4078393)
  • 4:20 PM – 4:30 PM: Nina Mirabadi, University of Washington, DETECTION OF POST-TRAUMATIC INFECTION AND SEPSIS USING QUANTITATIVE MDSC MEASUREMENTS (Abstract 4083215)
4:30 PM – 4:40 PM Refreshment Break

4:40 PM – 6:00 PM

Moderators
Steven Schwulst MD, Northwestern Medicine
Letitia Bible MD, University of Florida 

Parallel Session 5 – Improving Neurologic Outcomes following Injury and Sepsis

Invited Speakers

  • 4:40 PM – 5:00 PM: Kalev Freeman MD PhD, University of Vermont
    Echoes of Impact: Cardiovascular Sequelae of Traumatic Brain Injury
  • 5:00 PM – 5:20 PM: Steven Schwulst MD, Northwestern Medicine, 

    The gut-brain axis as a novel therapeutic target in traumatic brain injury

Oral Abstracts

  • 5:20 PM – 5:30 PM: Ravinder Nagpal, Florida State University, ENTERO-SEPTIC KLEBSIELLA PNEUMONIAE INFECTION AND PATHOBIOME INDUCE NEUROINFLAMMATORY AND COGNITIVE IMPAIRMENTS IN 3X TG MICE (Abstract 4083885)
  • 5:30 PM – 5:40 PM: Alyson Galvan-Lara, University of Kentucky, EFFECTS OF APOLIPOPROTEIN E POLYMORPHISM ON POST-SEPSIS COGNITIVE DYSFUNCTION (Abstract 4083204)
  • 5:40 PM – 5:50 PM: Mecca Islam, Northwestern University, SEX ASSOCIATED DIFFERENCES IN NEUROCOGNITIVE OUTCOMES AFTER TBI (Abstract 4083554)
  • 5:50 PM – 6:00 PM: Andrew Hoisington, US Department of Veterans Affairs Mental Illness Research Education and Clinical Centers, GUT MICROBIOME AND INFLAMMATION AFTER EMERGENCY DEPARTMENT VISIT FOR MILD TRAUMATIC BRAIN INJURY (Abstract 4077363)

4:40 PM – 6:00 PM

Extremes of Age and their Importance in Injury and Sepsis Research

Moderators
Dan Hao PhD, Vanderbilt University
Shawn Larson MD, University of Florida

Parallel Session 6

  • 4:40 PM – 4:50 PM: Ki Ho Park, University of Virginia, PRESERVING NEURONAL INTEGRITY AND MITIGATING INFLAMMATION TO COUNTER ISCHEMIC BRAIN INJURY IN AGING MICE (Abstract 4080581)
  • 4:50 PM – 5:00 PM: Grace Fisler, Steven, and Alexandra Cohen Children's Medical Center: CHARACTERIZATION OF CIRCULATING INNATE IMMUNE PROFILE IN EARLY PEDIATRIC SEPSIS (Abstract 4078779)
  • 5:00 PM – 5:10 PM: Jaimar Rincon, University of Florida, SINGLE-CELL TRANSCRIPTOME PROFILING REVEALS MYELOID-DERIVED SUPPRESSOR CELL (MDSC) HETEROGENEITY IN MURINE NEONATAL SEPSIS (Abstract 4083786)
  • 5:10 PM – 5:20 PM: Dan Hao, Vanderbilt University, TRAINED IMMUNITY ENHANCES HOST RESISTANCE TO INFECTION IN AGING
  • 5:20 PM – 5:30 PM: Hyebin Han, Northwestern University, FECAL MICROBIOTA TRANSPLANT WITH AGED GUT MICROBIOTA INCREASE SPECIES-NORMAL ANXIETY AS COMPARED TO YOUNG GUT MICROBIOTA (Abstract 4078779)
6:30 PM – 7:00 PM Cocktail ½ Hour
7:00 PM – 9:30 PM Dinner and Awards Banquet